From Genome Technology, 12.2.08:
A review by Australian researchers discusses the challenges in differentiating protein-coding and noncoding RNA. They go through a variety of strategies such as comparing open reading frame length or conservation, as well as structural and experimental approaches. They also wonder if this is a false dichotomy. "Looking ahead, we must also be prepared to cast off our historical biases toward what appears now to be an increasingly false dichotomy, and instead embrace the likelihood that RNA is a molecular multi-tasker," they write.