Friday, January 16, 2009

Research Link: RNA Viruses Invade Host DNA (Viral vs. RNA Conflict)

http://www.sciencemag.org/cgi/content/abstract/323/5912/393

"RNA viruses were believed not to integrate into the host's genome under any circumstances (check out HIV, Shingles, EB). We found that illegitimate recombination between an exogenous nonretroviral RNA virus, lymphocytic choriomeningitis virus, and the endogenous intracisternal A-type particle (IAP) retrotransposon occurred and led to reverse transcription of exogenous viral RNA (enemy at the gates). The resulting complementary DNA was integrated into the host's genome with an IAP element. Thus, RNA viruses should be closely scrutinized for any capacity to interact with endogenous retroviral elements before their approval for therapeutic use in humans."


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